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Beilstein J. Org. Chem. 2018, 14, 1946–1955, doi:10.3762/bjoc.14.169
Graphical Abstract
Figure 1: Schematic illustration of possible support-assisted methods.
Figure 2: Expected reactivity of 5’- and 3’-terminus for the activation.
Scheme 1: Competition experiment between alcohol and carboxylic acid. Reagents and conditions: (i) 4-phenylbu...
Scheme 2: Conjugation between the 5’-activated supported trinucleotide 2 and the tripeptide 3. Reagents and c...
Figure 3: HPLC spectra of the crude protected bioconjugate 4 and the crude deprotected bioconjugate 5.
Scheme 3: 5’-Phosphitylation of supported decanucleotide 13. Reagents and conditions: 2-cyanoethyl-N,N,N',N'-...
Scheme 4: Conjugation between 5’-activated supported decanucleotide 14 and supported pentapeptide 7. Reagents...
Figure 4: HPLC spectra of the crude protected bioconjugate 15 and the deprotected bioconjugate 16.